Endocrine Abstracts

IntroductionThe polycystic ovary syndrome (PCOS) affects about 6–10% of women of reproductive age and is associated with oligomenorrhoea and anovulation. Recently, a possible impairment of bone accrual in women with PCOS due to the chronic inflammation disposition has been postulated [Kalyan, 2017]. The lack of progesterone due to anovulation may also have effects on bone metabolism [Seifert-Klauss, 2015]. A progestin test is a classic tool for asse...

Background: Primary hyperparathyroidism may severely manifest with an adjusted calcium >3.5mmol/l and increased risk of prolonged postoperative hypocalcaemia. Formal consensus on preoperative optimisation appears lacking, especially around the utility of parenteral bisphosphonate treatment. Bisphosphonate therapy has been demonstrated to cause prolonged hypocalcaemia when given to patients with a history of parathyroidectomy....

Endocrine nursing practice has been changing, with the advent of more autonomous roles, involving nurse led clinics and independent prescribing, with more complex clinical case management. However, recent research highlights the emphasis on optimum patient care, but scope of practice is not always clear, leading to unequal balance in skills and capabilities, qualifications, and Agenda for Change (AfC) bandings. This study explored the remit, job components, and capabilities of...

Introduction: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of obesity and weight gain. Obesity negatively impacts the fertility, mental wellbeing and long term health of women with PCOS. The 2023 international guidelines for the management of PCOS suggest that GLP1 receptor agonists could be considered, but highlight a lack of evidence for medical obesity treatment in women with PCOS. Previous studies showed that interventions which red...

Polycystic ovary syndrome (PCOS) is a multifactorial, complex endocrine disorder affecting a significant proportion of the global population. Aberrant secretion and/or action of gonadotropins is implicated in PCOS, but, to date, we have only limited knowledge about the precise mechanisms involved. We therefore studied LHR expression, signalling and trafficking in GLCs from women with and without PCOS. GLCs from women with PCOS exhibited enhanced Gαs-cAMP signalling respon...

A previously healthy 12 year old girl presented to the emergency department with loss of consciousness and increased work of breathing. She was unwell for 3 days prior to presentation with vomiting and lethargy. There was a 3 week history of polydipsia and weight loss. On assessment, Glasgow Coma Scale (GCS) was 7/15, pupils size 3, equal but poorly responsive. She was hypertensive BP 140/70 mmHg, HR 113 bpm, and capillary refill time 5 seconds. There was left arm decorticate ...

Introduction: While there is a significant risk of recurrence in nonfunctioning pituitary adenoma (NFPA) after surgery, it is challenging to predict which NFPAs will recur based solely on routine histopathology. To better understand markers of recurrence, we assessed the established tumor markers linked to aggressive tumor behavior including X-linked IAP (XIAP), the most potent inhibitor of the apoptosis protein family, vascular epithelial growth factor (VEGF) which facilitate...

Patients with acromegaly (PWA) experience higher rates of falls and fall-related injuries than age-matched Canadian adults. Previous studies of standing balance revealed increased sway in PWA compared to healthy controls but failed to control for the effects of the pituitary adenoma. Therefore, the aim of the present study was to determine if acromegaly influenced the neuromuscular control of standing balance. Bipedal standing balance was evaluated in PWA (n=13) in bi...

Acromegaly triggers, and is associated with, peripheral nervous system modifications and joint degenerations, which are considered to impact the walking balance of patients with acromegaly (PWA). Therefore, to better understand if these systemic degenerations impact the transitory adaptations in locomotor patterns of these patients, this study aims to establish the walking balance deficits of PWA. Walking balance was evaluated in PWA (n=8) in biochemical remission and...

Acromegaly, characterized by growth hormone excess, adversely affects the patients’ musculoskeletal and neural systems, consequently impairing physical function. Previous studies have noted walking impairments in patients with acromegaly (PWA). This study aimed to characterize the kinematic and kinetic changes during walking in PWA. Kinematics and kinetics of walking were evaluated in PWA (n=8) in biochemical remission and a control group of patients with non-fun...